Thursday Night Football This Week brings a crucial NFC West showdown as the San Francisco 49ers face the Los Angeles Rams. Kickoff is Thursday, Oct. 2, 2025, at 8:15 p.m. ET from SoFi Stadium in Inglewood, California. The game will stream live on Prime Video and air on local TV affiliates in the teams’ home markets.
Both teams are 3–1 and looking to take early control of the division. San Francisco leads the all-time series but enters short-handed, while Los Angeles rides a three-game win streak against the 49ers. The outcome could shape NFC playoff seeding later this season.
49ers vs Rams: Odds, injuries, and how to watch
The Rams opened as modest home favorites but saw the line jump to -8.5 by Thursday morning after key San Francisco injuries. The over/under sits between 43.5 and 44.5 points. Moneyline odds hover near Rams -450 and 49ers +350.
San Francisco will start Mac Jones at quarterback after Brock Purdy was ruled out with a toe injury. Wide receivers Jauan Jennings and Ricky Pearsall are also sidelined. The team elevated Adrian Martinez for depth. Los Angeles expects most starters, though a few linemen and skill players were listed as questionable midweek.
The game will stream exclusively on Prime Video nationwide. In-market fans can watch on local network affiliates. Pregame coverage begins about an hour before kickoff, and official inactives drop 90 minutes before the start.
Sportsbook promos for Thursday Night Football
New users can find several attractive promos for tonight’s matchup. Many top sportsbooks are offering first-bet insurance up to $1,000–$1,500 in bonus bets if your first wager loses. Others provide “bet and get” bonuses, such as Bet $5 and get $200 in bonus credits after a qualifying first wager. Profit-boost tokens are also common for Thursday Night Football games, doubling or increasing payouts on select props and parlays. Always check the promo terms, including odds requirements and bonus expiration windows.
These offers can help bettors maximize value on tonight’s game. For example, using first-bet insurance on a moneyline or spread position provides safety if the underdog 49ers upset expectations. Profit boosts may work well on safer prop bets like Christian McCaffrey rushing yards or anytime touchdown scorer markets.
Why this matchup matters
The Rams’ defensive front could dictate the night. If they win the trenches, San Francisco may lean heavily on Christian McCaffrey and quick passing to Mac Jones. Both teams know this game could swing division standings. Short-week games often favor the home side, and Los Angeles has that edge.
Live bettors will watch early offensive line play, QB comfort, and third-down efficiency. Those indicators often swing in-game spreads and totals. With injuries piling up for San Francisco, any early struggles could widen the score quickly.
Bottom line: Thursday Night Football This Week features the 49ers at Rams, 8:15 p.m. ET on Prime Video. Los Angeles enters as a clear favorite after San Francisco’s injury setbacks. Bettors can explore promos and line value before kickoff.
FYI (keeping you in the loop)-
Q1: Who plays on Thursday Night Football this week?
The San Francisco 49ers visit the Los Angeles Rams in a Week 5 NFC West matchup.
Q2: What time and channel is the game tonight?
Kickoff is at 8:15 p.m. ET. The game streams on Prime Video and airs on local TV in home markets.
Q3: Who is starting at quarterback for the 49ers?
Mac Jones will start. Brock Purdy is sidelined with a toe injury, and Adrian Martinez was promoted for depth.
Q4: What are the latest odds for Rams vs 49ers?
Most books list the Rams as 7.5 to 9-point favorites. The total is around 43.5–44.5, and the Rams moneyline sits near -450.
Q5: Are there any notable sportsbook promos tonight?
Yes. Top books offer first-bet insurance up to $1,500, bet-and-get bonuses like Bet $5 Get $200, and profit-boost tokens for TNF props and parlays.
